Joint analysis of a linear regression model

Estimate the allelic effect size and the standard errors of the target SNP in the single SNP linear model.

meta_sel_joinest(sel.gwas, sel.ld, actual.geno)

Arguments

sel.gwas

A dataframe which contains the GWAS information for SNP set. GWAS information comprise "MARKERNAME","CHROMOSOME","POSITION","EA","NEA","EAF","N","BETA","SE".

sel.ld

A LD matrix containing the correlation between the SNP set.

actual.geno

An indicator to specify whether the true cohort-level LD structure is applied. If actual.geno is TRUE, the inputted LD structures are derived from the true individual-level genotype data.

Value

Output a data.frame containing the estimated allelic effect, standard error, the inverse of squared standard error and the p-value of association test for the target SNP.

Author

Siru Wang