This is an R package for performing environment-adjusted MR-MEGA analysis aggregating all involved GWAS data.
Website available: https://SiruRooney.github.io/env.MRmega/
For more details, please see:
S Wang, OO Ojewunmi, A Kamiza, M Ramsay, AP Morris, T Chikowore, S Fatumo, JL Asimit. Accounting for heterogeneity due to environmental sources in meta-analysis of genome-wide association studies. Communications Biology. 2024 Nov 14;7(1):1512. https://doi.org/10.1038/s42003-024-07236-9 PDF
Installation
Before installing R package of env.MRmega, the following packages from CRAN are required:
install.packages("data.table")
install.packages("doMC")
install.packages("doParallel")
install.packages("dplyr")
install.packages("iterators")
install.packages("parallel")
install.packages("R.utils")You can install the GitHub version of env.MRmega:
# install.packages("devtools")
devtools::install_github("SiruRooney/env.MRmega")